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关于两项关于COVID-19的活体系统的Cochrane评价的经验报告

Carina Wagner¹, Caroline Hirsch¹, Waldemar Siemens²

¹Department I of Internal Medicine, Evidence-based Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany.

Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

|January 14, 2024

概括

针对COVID-19治疗方法进行活体系统审查 (LSR) 提出了独特的挑战,包括调整研究设计和管理快速变化的证据. 这些见解为未来在快速新兴研究领域的LSR提供了宝贵的指导.

科学领域:

医学研究方法学医学研究方法学
证据综合证据综合
公共卫生公共卫生

背景情况:

更新的系统审查 (SRs) 对于基于证据的决策至关重要.
随着COVID-19的流行,人们越来越需要及时的证据,使得生活系统审查 (LSRs) 成为一个相关的方法.
虽然LSR是有益的,但在执行过程中存在着不同的挑战.

研究的目的:

分享实用见解和报告在两次Cochrane LSR期间遇到的关于COVID-19治疗的挑战.
分析关键组成部分的挑战:研究设计,出版类型,干预,结果,搜索策略,更新和报告.
为应对LSR挑战提供一个框架,借鉴康复性血和COVID-19系统性皮质类固醇的经验.

主要方法:

经验报告详细介绍了进行两次Cochrane LSR的过程.
基于已确定的组件对挑战的分析 (Iannizzi等人,2022).
对康复期血与全身皮质类固醇LSR面临的挑战的比较评估.

主要成果:

研究设计的适应性是关键,因为由于有限的RCT数据,早期的流行病审查包括多样化的设计.
挑战包括管理出版物类型 (例如,预印稿),定义干预措施/比较器 (例如,护理标准,变体) 和调整结果集.
文献搜索策略和审查更新标准需要根据新的证据,资源和政策相关性经常进行调整.

结论:

在两个LSR中观察到挑战的相似性和差异.
许多挑战源于流行病背景 (例如,不断变化的结果,数据库搜索调整).
学到的经验教训适用于LSR作者在其他快速发展的研究领域超越了大流行.

关键词:

在 COVID-19 疫情中,康复期间的血.这是一份经验报告.经验报告经验报告黎巴嫩的系统性审查活生生的系统性审查一个流行病的流行病.一个流行病的流行病.康复了百分之十的等离子体系统性皮质类固醇.系统性皮质类固醇类固醇

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