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相关概念视频

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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相关实验视频

Updated: Jul 5, 2025

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
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多模体运动和认知训练计划改善了在amnestic轻度认知障碍患者的认知功能

Jennifer Kaci Fairchild1, Jonathan Myers2, Peter Louras1

  • 1VISN 21 Mental Illness Research, Education, and Clinical Center (JKF, PL, MWM, JH, JY), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304; Department of Psychiatry and Behavioral Sciences (JKF, PL, BJ, MWM, JH, JY), Stanford University School of Medicine, Stanford, CA 94305.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
|January 14, 2024
PubMed
概括

这项研究发现,运动和认知训练的结合改善了老年轻度认知障碍患者的记忆和执行功能. 综合有氧和阻力运动组也显示了处理速度和功能能力的增长.

关键词:
有氧运动是有氧运动.退伍军人退伍军人退伍军人认知训练是一种认知训练.轻度的认知障碍 轻度的认知障碍耐力运动是一种抵抗运动.

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科学领域:

  • 老年学是一门学科.
  • 神经科学是一个神经科学.
  • 运动科学 运动科学

背景情况:

  • 患有无记忆性轻度认知障碍 (aMCI) 的老年人经常经历认知衰退.
  • 正在探索结合体育炼和认知训练的干预措施,以减轻认知障碍.

研究的目的:

  • 对于被诊断患有aMCI的老年人,研究联合体育炼和认知训练干预措施的初步疗效.
  • 为了比较联合有氧和抵抗运动加上认知训练 (CARE+CT) 与伸展运动加上认知训练 (SE+CT) 的效果.

主要方法:

  • 一项随机临床试验,涉及72名MCI的社区居民志愿者.
  • 参与者被分配到CARE+CT或SE+CT干预措施中.
  • 主要结局包括单词列表和名字-面孔回忆;二级结局评估认知领域,VO2最大值和功能能力.

主要成果:

  • 所有参与者都在延迟的单词列表回忆,学习,记忆和执行功能方面表现出改善.
  • CARE+CT小组在处理速度和功能能力方面取得了显著的改进.
  • APOE4状态影响了SE+CT组观察到的认知益处.

结论:

  • 初步证据支持在MCI患者中使用联合运动和认知训练干预措施.
  • 需要进一步的研究来阐明潜在的机制,并在不同的人群中测试这些干预措施.