胸部计算机断层扫描和COVID-19死亡率上的冠状动脉炎症
Domenico Tuttolomondo1, Andrea Ticinesi2,3, Damini Dey4
1Cardiology Unit, Azienda Ospedaliero-Universitaria di Parma, Via Antonio Gramsci 14, 43126, Parma, Italy.
冠状动脉周脂肪组织 (PCAT) 衰减,冠状动脉炎症的标志物,与严重的COVID-19患者的住院死亡率较高密切相关. 这种简单的CT扫描测量可以作为一个关键的预后指标.
科学领域:
- 心血管成像 - 心血管成像
- 传染性疾病 传染性疾病
- 放射学 放射学是指放射学
背景情况:
- COVID-19的死亡率受到年龄,并发病,炎症和病毒谱系的影响.
- 预测不良COVID-19预后的现有生物标志物有限.
- 周冠状动脉脂肪组织 (PCAT) 衰减是一种冠状动脉炎症的新标志物.
研究的目的:
- 评估PCAT减弱在严重COVID-19的预后作用.
- 评估PCAT作为COVID-19患者住院死亡率的潜在生物标志物.
主要方法:
- 意大利在第一波和第三波期间住院的769名COVID-19患者的回顾性招生.
- 收集人口,临床,实验室和高分辨率胸部CT (HRCT) 数据.
- 对冠状动脉分数和PCAT减弱的分析,从HRCT对住院死亡率的相关性进行分析.
主要成果:
- 住院死亡率为28% (214/769名患者).
- 多变量分析确定了年龄,慢性疾病,吸烟,P/F比,血小板计数,肌素,机械呼吸,HRCT视觉得分和PCAT衰减作为死亡率的独立预测因素.
- PCAT减弱与死亡率有显著的相关性 (p < 0.001),而冠状动脉分数则没有.
结论:
- 在HRCT上测量的PCAT减弱独立地与严重COVID-19的住院死亡率增加有关.
- 冠状动脉炎症,PCAT表示,是一个显著的预后因素,独立于动脉样硬化负担.
- 对于COVID-19患者来说,PCAT可以作为一种有价值,易于获得的预后标志物.
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