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在纯血统的马匹中,近亲繁殖是否会导致怀孕流产?

Jessica M Lawson¹, Charlotte A Shilton², Victoria Lindsay-McGee³

¹Department of Pathobiology and Population Sciences, The Royal Veterinary College, University of London, Hatfield, UK.

Equine veterinary journal

|January 15, 2024

概括

基因组内生育与纯血犬中期和晚期妊娠损失有关,但与早期妊娠损失无关. 这凸显了谨慎选择交配的重要性,以避免致死性等位基因的同性增加.

科学领域:

马类基因组学马类基因组学
生殖科学生殖科学
动物遗传学动物遗传学

背景情况:

过度的近亲繁殖增加了同卵性衰退基因型的风险,与保留的胎盘和马的精液质量差有关.
之前没有任何基因组研究探讨了近亲繁殖水平和纯血犬的怀孕损失之间的联系.

研究的目的:

为了比较患有早期怀孕损失 (EPL),中期和晚期怀孕损失 (MLPL) 和对照的纯血犬的遗传亲生生系数 (F).
为了研究同胞繁殖水平在与对照群相比,怀孕流产的马的水平更高的假设.

主要方法:

一项观察性病例对照研究,利用纯血动物的DNA.
用Axiom Equine 670K SNP Genotyping Array进行了基因型鉴定.
亲生生殖系数是通过PLINK软件使用Runs of Homozygosity (FROH) 来计算的,ROH被按大小分类以评估亲生生殖的近期性.

主要成果:

与对照组相比,中期和晚期怀孕损失 (MLPL) 病例的数量,长度和同卵性运行 (ROH) 总数显著增加,F_ROH值增加.
在早期妊娠损失 (EPL) 病例和对照之间没有发现内生育指数的显著差异.
在MLPL病例中,长ROH (>10 Mb) 的比例比对照组更高,这表明最近的近亲繁殖.

结论:

基因组杂交导致英国纯血犬中期和晚期怀孕损失 (MLPL),但不是早期怀孕损失 (EPL).
交配决定至关重要,因为近亲繁殖可以增加有害等位基因的同胞性可能性,使马患上MLPL.
这项研究提供了第一个基因组证据,将近亲繁殖水平与纯血犬特定类型的妊娠损失联系起来.

关键词:

堕胎堕胎堕胎堕胎堕胎堕胎堕胎堕胎胎儿胎儿胎儿胎儿同性异性性质是同性异性的.马的马,马的马,马的马,马的马.海洋的海洋海洋的海洋.流产流产流产流产

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