过度活动膀的黑盒子:中心敏感化及其与尿路症状严重程度和生活质量之间的关系
Seyda T Celenay1, Hafize Altay2, Saliha B Bulbul3
1Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Ankara Yildirim Beyazit University, Ankara, Turkey.
Neurourology and urodynamics
|January 15, 2024
概括
几乎一半患有过度活动膀 (OAB) 的女性经历中央敏感化 (CS). 更严重的CS症状与OAB患者的尿道问题增加和生活质量 (QoL) 降低相关.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 神经科学是一个神经科学.
- 精神病体医学是一种精神病体医学.
背景情况:
- 过度活跃的膀 (OAB) 显著影响女性的生活质量 (QoL).
- 中央敏感性 (CS) 是一种神经机制,可能导致慢性疼痛和感官功能障碍.
- 在OAB症状严重程度和QoL中CS的作用需要进一步调查.
研究的目的:
- 确定诊断出膀过活 (OAB) 的妇女中中央敏感性 (CS) 的患病率.
- 探索CS症状的严重程度与OAB妇女尿道症状严重程度之间的关联.
- 调查CS与OAB女性所经历的生活质量 (QoL) 之间的关系.
主要方法:
- 一组144名患有OAB的女性参与了这项研究.
- 中央敏感化库存 (CSI) 评估了CS.
- 使用过度活跃膀问卷第8版 (OAB-V8),膀日记和患者对紧迫性强度感知量表 (PPIUS) 评估了尿液症状的严重程度.
- 使用国王健康问卷 (KHQ) 来衡量生活质量 (QoL).
主要成果:
- 中心敏感性 (CS) 在47.9%的膀过活 (OAB) 的女性中被确定.
- 较高的CSI分数与OAB-V8分数增加 (p < 0.001) 和每天空洞平均数量增加 (p < 0.001) 有显著的相关性.
- 患有OAB和CS的妇女在多个KHQ领域报告了明显更高的紧急严重程度 (p = 0.006) 和较差的QoL,包括失禁影响,个人关系,睡眠/能量,情绪状态和整体严重程度测量 (所有p <0.05).
结论:
- 大多数患有过度活动膀 (OAB) 的女性表现出中央敏感性 (CS) 的症状.
- 脑脊髓炎的严重程度增加与OAB患者更明显的尿路症状严重程度和生活质量 (QoL) 降低直接相关.
- 评估CS对于全面的OAB管理和定制有效的治疗策略至关重要.
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