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在膀癌中对周围血液和瘤免疫微环境的详细分析进行了匹配分析

Ji-Qing Chen¹, Lucas A Salas¹, John K Wiencke²

¹Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03766, USA.

|January 15, 2024

概括

膀瘤中的免疫细胞简介与血液不同,但不同的患者群体显示共享TME和血液免疫变化. 了解这些瘤-系统性免疫联系对于癌症治疗至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

膀癌治疗反应取决于瘤微环境 (TME) 和血液免疫特征.
有限的研究存在于瘤透免疫细胞和外围免疫特征之间的联系.

研究的目的:

研究瘤微环境中的免疫细胞组成与膀癌患者的周围血液之间的关系.
识别不同的免疫特征及其与临床结果的相关性.

主要方法:

利用DNA甲基化细胞计量来量化TME和匹配的外周血液样本中的免疫细胞比例.
根据TME免疫透状态将患者分组为使用的共识集群.

主要成果:

被归类为"免疫热"或"免疫冷"的患者表现出明显的TME免疫组成,但在循环血液免疫细胞中没有显著差异.
共识集群确定了两个患者集群,在TME和外周血液中具有不同的免疫组成.

结论:

使用甲基化细胞计的详细免疫分析强调了分析瘤和全身免疫的重要性.
了解瘤特异性和全身免疫反应之间的相互作用对于推进膀癌患者护理和治疗至关重要.

关键词:

通过DNA甲基化.膀癌:膀癌是一种癌症.循环免疫特征的循环免疫特征免疫特征免疫特征甲基化细胞计量方法瘤微环境是一个微环境.

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The Tumor Microenvironment

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