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细胞衰老程序对聚合物组织支架中的物理差异敏感

Parul Yadav1, Rahul Shah2, Anindo Roy2

  • 1Department of Bioengineering, Indian Institute of Science, C.V Raman Avenue, Bangalore, India 560012.

ACS materials Au
|January 15, 2024
PubMed
概括

基质设计影响细胞衰老. 三维支架,与二维培养不同,由于细胞扩散和相互作用的变化,显著改变细胞大小和衰老诱导.

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...