哈吉班德赫指数在确定急性腹部腹膜污染的预测价值:一个队列研究和元分析
Shahab Hajibandeh1, Shahin Hajibandeh2, Louis Evans3
1Department of General Surgery, University Hospital of Wales, Cardiff CF14 4XW, United Kingdom. shahab_hajibandeh@yahoo.com.
World journal of gastrointestinal surgery
|January 15, 2024
概括
哈吉班德指数 (HI) 准确地预测了急性腹部病理中的腹膜污染. 这项研究验证了HI的有效性.
科学领域:
- 手术病理学的外科病理学
- 诊断的准确性 诊断的准确性
- 生物标志物 生物标志物
背景情况:
- 哈吉班德赫指数 (HI) 是一种复合生物标志物,在预测腹膜污染和急性腹部疾病中的死亡率方面表现有前途.
- 准确预测腹膜污染对于及时的手术干预和改善患者结果至关重要.
研究的目的:
- 为了验证HI的诊断性能,在一个更大的队列中预测腹膜污染的存在和性质.
- 进行系统性审查和元分析,以综合现有关于HI预测准确性的证据.
主要方法:
- 根据STROBE和PRISMA的指导方针,进行了一项前性队列研究 (ChiCTR2200056183) 和一个系统审查/元分析 (CRD42022306018).
- 包括因急性腹部病理而接受紧急腹腔切除术的成年患者.
- 使用接收器操作特征 (ROC) 曲线分析和曲线下面面积 (AUC) 的元分析来评估诊断准确性.
主要成果:
- 队列研究 (n=700) 表明HI的预测准确性很强,AUC为不同类型的污染物,范围为0.76至0.83.
- 分析 (n=1437) 证实了这些发现,显示HI的AUC在0.78和0.80之间.
- HI显示了污染存在,性污染和污染的显著预测值 (P < 0.0001).
结论:
- 哈吉班德指数是急性腹部病理患者腹腔内污染的强大而准确的预测指标.
- 虽然证据强有力的,进一步的独立验证是鼓励的,特别是预测死亡率后的紧急腹腔切除术.
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