COVID-19治疗和精神药物之间的药物相互作用:一项更新的研究
Ujwal Boppana1, Thomas S Leonard1, Ayodeji Jolayemi1
1Psychiatry, Interfaith Medical Center, Brooklyn, USA.
Cureus
|January 15, 2024
概括
像Paxlovid这样的较新的COVID-19治疗方法可能与精神药物相互作用,需要仔细监测. 其他治疗方法,如甲,相互作用较少,但所有患者都需要密切观察安全性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 最近COVID-19治疗的进展为管理精神药物相互作用带来了挑战.
- 现有的临床指南不涵盖较新的COVID-19药物,因此需要更新建议.
- 患有精神疾病的患者需要仔细管理COVID-19疗法和精神药物之间的药物相互作用.
研究的目的:
- 审查和总结当前的COVID-19治疗和精神药物之间的潜在药物相互作用.
- 为医疗保健提供者提供易于解释的信息来管理这些互动.
- 为接受两种类型药物的患者选择合适的治疗计划提供指导.
主要方法:
- 在COVID-19和精神药物治疗患者中对药物相互作用和结果进行了文献搜索.
- 分析药物数据库以选潜在的相互作用.
- 审查的重点是关键的COVID-19治疗方法:帕克斯洛维德,雷梅西维尔,德克萨米他,托西利祖马布和巴里西替尼.
主要成果:
- 帕克斯洛维德 (nirmatrelvir/ritonavir) 显示出与抗精神病药物和抗焦虑药物的潜在显著相互作用,往往需要监测或剂量调整.
- 德克萨米他松,雷姆迪西维尔,托西利祖马布和巴里西提尼布与精神药物相互作用的报道较少.
- 虽然建议对后者进行一些监测,但通常不需要进行重大调整.
结论:
- 医疗保健提供者必须仔细考虑和监测COVID-19治疗和精神药物的联合使用.
- 更新的指导对于减轻与这种患者群体中药物相互作用相关的风险至关重要.
- 确保患者安全需要对心理药物和COVID-19药物治疗方案的警管理.
相关概念视频
Drug Therapy
45
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
45
Psychosis: Goals of Pharmacotherapy
133
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
133
Psychosis and Antipsychotic Drugs: Overview
263
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
263
Antidepressant Drugs: MAOIs and Other Agents
237
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
237
Antidepressant Drugs: Overview
493
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
493
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
394
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
394


