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计算机模拟预测了神经元缩对亨廷顿病动态的影响

Sara Sameni1,2, Thomas M Bartol2, Jody Corey-Bloom3

  • 1Division of Biological Sciences, University of California, San Diego, CA 92093, USA.

PNAS nexus
|January 15, 2024
PubMed
概括

亨廷顿病 (HD) 导致神经元缩和运动缺陷. 计算模型显示,细胞收缩增加了内细胞网膜的释放,损害了线粒体,并在HD中损害了细胞功能.

关键词:
亨廷顿病就是亨廷顿病.衰老的衰老 衰老的衰老生物标志物 生物标志物代谢过程中的代谢.计算模型是一种计算模型.

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...