构成性法律对红细胞膜对大菌株的反应的影响
Marianna Pepona1, John Gounley2, Amanda Randles1
1Department of Biomedical Engineering, Duke University, Durham, NC, USA.
概括
这项研究比较了三个红细胞膜模型 (Skalak,新胡克,Yeoh) 的细胞变形. 和新胡克的模型更好地捕捉红细胞 (RBC) 膜在机械应力时的折叠和纹.
科学领域:
- 生物物理学的生物物理.
- 计算生物学 计算生物学
- 材料科学 材料科学 材料科学
背景情况:
- 红细胞膜机制对于了解红细胞 (RBC) 的行为至关重要.
- 需要准确的构成定律来在各种条件下建模RBC变形.
研究的目的:
- 从理论和数值上分析Skalak,新胡克和Yeoh构成定律对红细胞膜机制的准确性.
- 通过光学子和微管管吸入实验,在非线性变形状态下评估这些模型.
主要方法:
- 理论分析和数值调查三个组成的法律 (斯卡拉克,新胡克,Yeoh).
- 模拟红细胞变形使用光学子和微管吸收.
- 建立剪切弹性模块和张力变形之间的关系.
主要成果:
- 所有法则都充分预测了在恒定剪切模量下在光学下变形的情况.
- 新胡金和叶定律复制了观察到的红细胞膜折叠,但具有区域变化.
- 约氏定律很好地预测了微管管的吸收,新胡克和约氏定律复制了膜纹.
结论:
- 与斯卡拉克定律相比,Yeoh和新胡克定律在模拟红细胞膜折叠和纹方面提供了更高的准确性.
- 模型的选择取决于特定的变形模式和膜面积变化所需的精度.
相关概念视频
Hooke's Law
390
Hooke's law, a pivotal principle in material science, establishes that the strain a material undergoes is directly proportional to the applied stress, defined by a factor called the modulus of elasticity or Young's modulus.
390
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
267
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
267
Shearing Strain
283
The shearing strain represents a cubic element's angular change when subjected to shearing stress. This type of stress can transform a cube into an oblique parallelepiped without influencing normal strains. The cubic element experiences a significant transformation when exposed solely to shearing stress. Its shape alters from a perfect cube into a rhomboid, clearly demonstrating the effect of shearing strain. The degree of this strain is considered positive if it reduces the angle between...
283
Structure and Function of Erythrocytes
1.9K
There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
1.9K
Generalized Hooke's Law
937
The generalized Hooke's Law is a broadened version of Hooke's Law, which extends to all types of stress and in every direction. Consider an isotropic material shaped into a cube subjected to multiaxial loading. In this scenario, normal stresses are exerted along the three coordinate axes. As a result of these stresses, the cubic shape deforms into a rectangular parallelepiped. Despite this deformation, the new shape maintains equal sides, and there is a normal strain in the direction of the...
937
Factors Affecting Erythropoiesis
3.3K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.3K


