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用于制备和描述具有不同比例的超细酸胺的超细酸胺

Dan Liang1, Wenjing Zhang1, Xiaoan Wei1

  • 1School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

ACS omega
|January 15, 2024
PubMed
概括

超精细的化 (NQ) 制备具有改进的机械性能和热稳定性. 降低颗粒面积比提高了热稳定性和激活能量,而不会影响冲击灵敏度.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...