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工程温度响应的聚合物纳米粒子,加载和释放低分子量抗癌药物paclitaxel

Hiroyuki Koide¹, Kazuma Yamaguchi¹, Keijiro Sato¹

¹Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.

|January 15, 2024

概括

研究人员开发了温度敏感的聚合物纳米粒子 (NP),可以捕获和释放像帕克利塔克塞尔 (PTX) 这样的抗癌药物. 优化NP结构可以根据温度变化控制药物输送.

科学领域:

聚合物科学聚合物科学
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

聚N-异烯胺) (pNIPAm) 呈现了取决于温度的水友性/疏水性变化.
基于pNIPAm的纳米粒子 (NP) 在其较低的临界溶液温度 (LCST) 上缩小,在此以下膨胀.
有效的药物输送需要能够捕获和释放低分子量药物的纳米粒子.

研究的目的:

为了设计基于pNIPAm的NP,以对温度敏感的捕获和释放抗癌LMWD,抗癌LMWD的帕克利塔塞尔 (PTX).
研究NP膨胀比对不同点分子释放的影响.
引导刺激反应性聚合物的设计,以实现向药物输送.

主要方法:

制造基于pNIPAm的聚合物纳米粒子.
纳米粒子尺寸变化与温度 (膨胀比) 的表征.
基于温度依赖的NP胀的帕克利塔塞尔 (PTX) 和梅利丁捕获和释放的评估.

主要成果:

工程NP在LCST上方捕获了帕克利塔塞尔 (PTX),并在LCST下方释放.
膨胀比率>1.90的NP在冷却时有效释放PTX.
具有1.14的膨胀比率的NP释放了梅利丁,表明基于NP属性的目标特定释放.

结论:

在温度敏感的NP中优化功能性单体对于控制目标分子的捕获和释放至关重要.
NP的膨胀过渡和亲和度调整决定了它们释放特定LMWD的能力.
这些发现为设计用于药物输送应用的先进刺激响应聚合物提供了框架.

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