对于pH敏感的烯酸聚合物用于用于结肠释放的口服药物的涂层
Lina M Suárez1,2, Lina Hoyos3, Miquel Castellote-Borrell4,2
1Laboratorio de Investigación en Polímeros, Instituto de Química, Universidad de Antioquia, Medellín 050010, Colombia.
ACS omega
|January 15, 2024
概括
开发了对pH值敏感的聚合物涂层,用于口服药物输送. 定制的烯酸聚合物在胃肠道中提供受控释放,具有针对结肠药物输送优化的特定配方.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 制药科学 制药科学
背景情况:
- 口服药物输送系统面临的挑战来自胃肠道疾病,如低pH值和周围静止.
- 聚合物涂层具有药物传递的潜力,但需要优化稳定性和释放性.
- 对pH敏感的聚合物对于在特定的胃肠道环境中向药物释放至关重要.
研究的目的:
- 开发和表征用于基甲基纤维素 (HPMC) 囊的pH敏感聚合物涂层.
- 评估这些涂料在控制药物释放,特别是结肠输送方面的性能.
- 为了确定生物相容和有效的结肠药物释放的最佳配方.
主要方法:
- 通过乳液聚合合成烯酸聚合物 (甲基烯酸,甲基烯酸,甲基烯酸) 的合成.
- 聚合物属性的表征:颗粒大小,分子量和玻璃过渡温度.
- 使用浸泡方法对HPMC囊进行涂层,并评估不同pH值 (胃和肠道) 的药物释放率.
主要成果:
- 聚合物表现出适合薄膜形成和涂层应用的特性.
- 涂层HPMC囊在胃pH (1.2) 时显示出保护,在肠pH (7.2) 时显示出溶解.
- 甲基酸含量增加延长了药物释放时间, 7:3:3配方显示有望在没有细胞毒性的情况下进行结肠分娩.
结论:
- 化学调节的烯酸单体比允许定制的聚合物涂层,具有可调节的释放动力学.
- 开发的烯酸聚合物涂层有效控制胃肠道中药物释放.
- 甲基烯酸,甲基烯酸和甲基酸的特定7:3:3配方为结肠药物输送提供了一个生物相容的溶液.
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