1,4-二氨基酸和1,4-二氨基酸替代的芳香衍生物选择性抑制α-Synuclein寡合体形成在体外

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Updated: Jul 5, 2025

A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model
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A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model

Published on: November 25, 2022

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Susantha K Ganegamage1, Eduardo Ramirez1, Heba Alnakhala2

  • 1Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States.

ACS omega
|January 15, 2024
PubMed
概括

研究人员开发了新的尿素和硫尿素化合物,以抑制α-synuclein聚合,这是帕金森病 (PD) 的关键过程. 化合物1在减少细胞内含物方面表现有希望,为PD提供了潜在的治疗途径.

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