在患有肝病的患者中,PIVKA-II与肝功能,骨代谢和肌肉功能有关
Takuya Honda1,2, Tatsuki Ichikawa3,4,5, Mio Yamashima3
1Clinical Oncology Center, Nagasaki University Hospital, Nagasaki 852-8501, Japan.
Biomedical reports
|January 15, 2024
概括
在肝病患者中,由维生素K缺失-II (PIVKA-II) 诱导的蛋白质含量升高表明骨和肌肉代谢异常. 这一发现表明PIVKA-II可能有助于评估骨肌健康,并指导维生素K和维生素D补充.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床生物化学 临床生物化学
- 营养科学 营养科学
背景情况:
- 维生素K缺失诱导的蛋白-II (PIVKA-II) 是肝瘤诊断标志物,但其在非肝瘤患者中的重要性需要澄清.
- 维生素K (VK) 影响肌肉和骨代谢,这表明PIVKA-II与这些生理过程之间存在潜在的联系.
研究的目的:
- 在没有肝瘤或肝病的患者中评估血清PIVKA-II水平的临床意义.
- 在患有各种肝病的患者中,将PIVKA-II水平与骨和肌肉代谢标志物进行比较.
主要方法:
- 在441名肝病患者 (236名女性) 中分析了血清PIVKA-II水平和临床因素.
- 评估的骨标记物: I 型公原N-终端 (P1NP),低碳化骨质卡尔辛 (ucOC) 和25(OH) 维生素D (VD).
- 评估的肌肉标记:SARC-F得分和握力.
主要成果:
- 升高的PIVKA-II与严重的肝病 (儿童B/C),女性异常骨标记 (高P1NP,低ucOC),男性与酒精相关的肝病和低VD相关.
- 在女性中,PIVKA-II水平与免疫球蛋白A和PT-INR相关,在男性中与纤维化-4,IgG,胆红素,PT-INR和SARC-F相关.
- PIVKA-II表明女性的骨生理异常,男性的肌肉衰弱,以及整体严重的肝病.
结论:
- 血清PIVKA-II水平可以作为评估肝病患者骨肌代谢状态的指标.
- 有针对性的营养和脂肪溶性维生素 (VK,VD) 补充可能会减轻这一群体的骨肌病理学.
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