社区药剂师对评估晚期慢性病患者的功能和药物剂量的看法:使用理论领域框架进行定性研究
Jaclyn Tran1, Connor Shaffelburg2, Emma Phelan3
1Pharmacy Department, Nova Scotia Health, Halifax.
概括
社区药剂师可以改善慢性病患者的药物安全性. 了解药剂师对功能评估和药物剂量的看法是开发有效干预措施的关键,以便在CKD人群中更安全地开处方.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 功能显著影响药物排出,需要在慢性病 (CKD) 患者中调整剂量.
- 尽管有可用的资源,不适当的药物处方仍然是患有CKD的个体面临的风险.
- 社区药剂师处于战略地位,可以在这个脆弱的患者群体中提高药物安全性.
研究的目的:
- 探索社区药剂师对评估功能和调整晚期CKD患者的药物剂量 (eGFR<30 mL/min/1.73 m2) 的观点.
- 确定影响药剂师在CKD患者药物管理中的实践因素.
- 收集关于在社区药房设置中进行CKD管理的最佳工具的反.
主要方法:
- 一项定性研究,涉及12名社区药剂师的半结构化虚拟访谈.
- 理论领域框架以面试问题和主题分析为指导.
- 在NVIVO 12 Pro.中使用演和归纳编码分析了字面转录.
主要成果:
- 出现了四个主要主题:资源,环境,反思和领导/治理,涵盖了影响功能评估和剂量的10个类别.
- 药剂师强调了信息获取,技术,药房基础设施和协作实践的重要性.
- 实施改进的CKD管理工具的支持因素包括增强的知识,技能和支持性的实践环境.
结论:
- 研究结果为开发有针对性的干预措施提供了关键的见解,以改善社区药房中对功能障碍的药物评估和剂量.
- 解决确定的主题可以加强功能评估和高风险药物管理的整合到常规社区药房实践中.
- 未来的干预措施应侧重于教育,培训和培养支持性环境,以优化药剂师在CKD护理中的角色.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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01:11Renal Failure: Dose Adjustments
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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01:09Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions
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Renal clearance plays a pivotal role in drug elimination from the body and can be influenced by drug distribution and interactions. Understanding these factors is crucial in pharmacology as they impact the effectiveness and duration of drug therapy.
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134
01:06Renal Drug Clearance: Overview
204
Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
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01:22Heart Failure Drugs: Diuretics
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01:06Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
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