在急性精神分裂症患者中中性粒细胞-淋巴细胞比率
Shutaro Sugita1, Hiroi Tomioka2, Kensuke Mera1
1Department of Psychiatry, Showa University School of Medicine, Tokyo, JPN.
Cureus
|January 15, 2024
概括
中性粒细胞-淋巴细胞比率 (NLR) 和中性粒细胞-白蛋白比率 (NAR) 可以帮助确定急性精神分裂症的严重程度. 升高的NLR和NAR表明更严重的症状,并指导需要静脉注射利的患者的治疗决策.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物标志物 生物标志物
背景情况:
- 神经炎症与精神分裂症症状严重程度有关.
- 中性粒细胞-淋巴细胞比率 (NLR) 和中性粒细胞-白蛋白比率 (NAR) 是各种疾病的潜在生物标志物,包括精神分裂症.
- 需要客观的生物标志物来指导精神分裂症急性治疗决策.
研究的目的:
- 调查中性粒细胞-淋巴细胞比率 (NLR) 和中性粒细胞-白蛋白比率 (NAR) 作为急性精神分裂症严重程度的生物标志物.
- 评估NLR和NAR在确定精神分裂症患者治疗反应中的有用性.
主要方法:
- 对251名精神分裂症住院患者进行了回顾性检查.
- 基于急性阶段治疗的分类:静脉注射的哈洛佩里多尔与口服抗精神病药物.
- 在住院护理期间分析NLR和NAR水平.
主要成果:
- 静脉注射哈洛佩里多尔 (n=48) 组比口服抗精神病药物组 (n=208) 有更严重的急性症状和更高的临床全球印象严重性 (CGI-S) 评分.
- 中性粒细胞-淋巴细胞比率 (NLR) 和中性粒细胞-白蛋白比率 (NAR) 在静脉注射哈洛佩里多尔组显著更高.
- 升高的NLR和NAR与急性精神分裂症的症状严重程度增加相关.
结论:
- 升高的NLR和NAR对于需要急性治疗的精神运动动荡患者来说是易于测量的生物标志物.
- NLR和NAR对于在需要静脉注射哈洛佩里多尔治疗急性精神运动刺激的患者中确定疾病严重程度和治疗效果是有用的.
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