在亚临床甲状腺功能障碍症中评估骨转化标记物,如骨质保护素,硬质素和Dickkopf-1等
Ayşe Elverdi Özbek1, Hüseyin Korkmaz2, Mehmet Sözen3,4
1Department of İnternal Medicine, Selcuk University, Konya, Turkey.
Indian journal of clinical biochemistry : IJCB
|January 15, 2024
概括
亚临床甲状腺功能障碍症 (SH) 显著降低骨质保护素 (OPG) 水平,影响骨代谢. 这表明SH与骨折风险增加有关,需要对受影响的患者进行仔细评估.
科学领域:
- 内分泌学和骨代谢 骨质代谢
背景情况:
- 亚临床甲状腺功能障碍 (SH) 是一种状况,甲状腺激素水平升高,但没有明显的症状.
- 骨代谢是复杂的,可以受到各种激素失衡的影响.
- 骨质保护素 (OPG),硬质素和Dickkopf-1 (DKK1) 是骨重塑的关键调节剂.
研究的目的:
- 评估亚临床甲状腺功能障碍 (SH) 对骨代谢的影响.
- 在SH患者中评估骨质保护素 (OPG),硬质素和Dickkopf-1 (DKK1) 的水平.
- 为了确定SH和骨折风险之间的关联.
主要方法:
- 一项涉及40名SH患者和40名无甲状腺控制者的横截面前性研究.
- 使用ELISA测量血清OPG,硬质素,DKK-1,类型-1公原,C终端多 (CTx) 和尿液N终端端 (NTx).
- 通过DEXA评估骨矿物质密度 (BMD),使用FRAX估计骨折风险.
主要成果:
- 与对照组相比,SH组的血清OPG水平明显较低 (P=0.017).
- 在硬质素,DKK1,CTx或NTx水平上没有发现显著差异.
- 发现OPG水平与关节骨折风险之间存在负相关性 (rho=0.233,P=0.038).
结论:
- 亚临床甲状腺功能障碍明显影响血清骨质保护素 (OPG) 水平.
- OPG水平似乎与骨质疏松性骨折风险有关,特别是部骨折.
- SH与骨折风险有显著的关联,突出了这些患者骨折风险评估的重要性.
![Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58491.jpg&w=3840&q=50)
相关概念视频
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
01:20Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
01:40Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
01:31Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K