异常的大脑功能枢纽和因果有效连接在没有光环的月经相关和非月经相关的偏头痛
Xiaobin Huang1, Yujia Gao1, Tong Fu1
1Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Quantitative imaging in medicine and surgery
|January 15, 2024
概括
没有光环的月经偏头痛 (MRM) 患者表现出大脑网络的改变,特别是在insula. 这些变化影响认知和情绪处理,为偏头痛机制提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 没有光环的月经偏头痛 (MRM) 在女性偏头痛患者中很普遍,并且与大脑功能障碍有关.
- 在MRM患者中,全脑网络和定向功能连接的精确变化仍然不完全理解.
研究的目的:
- 研究与非月经性偏头痛没有光环 (NMM) 患者相比,MRM患者的静止状态功能网络和定向功能连接的变化.
- 使用功能磁共振成像 (fMRI) 具有中心度 (DC) 和格兰杰因果分析 (GCA) 来检测这些网络变化.
主要方法:
- 一项涉及45名MRM和40名NMM患者的回顾性,横截面研究,根据年龄,性别和教育情况进行了匹配.
- 休息状态fMRI数据使用DC和GCA进行分析,统计显著性设置为voxel水平P<0.01和集群水平P<0.05 (高斯随机场校正).
- 相关性分析检查了fMRI发现和临床特征之间的关系 (Bonferroni修正).
主要成果:
- 与NMM患者相比,MRM患者在右侧胰岛显示DC降低.
- 在MRM患者中,从右侧胰岛到侧中圈和逆侧上圈的有效连接得到了加强.
- 在MRM患者中,从右下尾环,左中前环,右前环和左下尾环到右脑岛的有效连接性有所下降.
- MRM 组报告了更高的焦虑分数和疾病持续时间和右胰岛DC之间的负相关性.
结论:
- MRM与中断的静止状态功能网络有关,这些功能网络以岛屿为中心.
- 这些被破坏的网络涉及到对认知过程,情绪感知和偏头痛发作至关重要的大脑区域.
- 这些发现提高了对月经偏头痛背后的神经生物学机制的理解.
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