宏观维生素B12是导致虚假升高的可巴胺水平的原因
1Hasselt University, Agoralaan, Hasselt, Belgium.
European journal of case reports in internal medicine
|January 15, 2024
概括
宏观维生素B12可以导致虚假的维生素B12水平升高,即使没有补充. 使用聚乙烯糖醇 (PEG) 沉的特定测试可以区分真正的维生素B12过度维生素与这种情况.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
- 临床化学 临床化学
背景情况:
- 血中维生素B12度升高通常与过度补充有关.
- 然而,在不服用补充剂的情况下,也可能出现无法解释的高维生素B12水平.
- 宏观维生素B12是一种经常被忽视的高血可巴胺的原因.
研究的目的:
- 为了调查一个持续高维生素B12水平的病例,患者拒绝补充.
- 为了突出宏维生素B12所带来的诊断挑战.
- 为了强调聚乙烯糖醇 (PEG) 沉在区分真正的维生素B12升高中的实用性.
主要方法:
- 一个案例研究,一个70岁的男性患有无法解释的高维生素B12水平.
- 诊断工作包括成像 (X射线,CT,PET-CT) 和程序 (结肠镜).
- 在聚乙烯糖醇 (PEG) 沉后,重新评估了维生素B12水平.
主要成果:
- 该患者被诊断患有肺腺癌,并进行了手术治疗.
- 尽管癌症治疗成功,但维生素B12水平仍然很高.
- 在PEG降水后,维生素B12水平正常化,表明存在宏观维生素B12.
结论:
- 无法解释的高维生素B12水平需要考虑宏观维生素B12.
- PEG沉对于区分宏维生素B12和真正的维生素B12过度维生素症至关重要.
- 高维生素B12的测量并不总是反映出足够的身体储量;PEG测试有助于准确的评估.
相关概念视频
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences
474
Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
474
Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K


