蛋白尿症查和骨折风险:一项回顾性队列研究,使用基于全国人口的数据库
Akira Okada1, Akira Honda2, Hideaki Watanabe3
1Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Clinical kidney journal
|January 15, 2024
概括
蛋白尿症增加了部或脊椎骨折的风险,即使考虑到功能. 对蛋白尿的监测对于预测患者骨折风险至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 整形外科 整形外科 整形外科
- 流行病学 流行病学
背景情况:
- 蛋白尿是病进展,心血管问题和癌症的已知危险因素.
- 之前关于功能障碍和骨折之间的联系的研究是不确定的,可能因蛋白尿而混.
- 这项研究调查了蛋白尿和骨折风险之间的独立关联.
研究的目的:
- 评估蛋白尿与部或脊椎骨折风险之间的关联.
- 为了澄清蛋白尿在骨折发展中的作用,独立于功能.
- 利用日本庞大的行政索赔数据库进行强有力的分析.
主要方法:
- 对DeSC数据库的回顾性分析 (2014年8月 - 2021年2月).
- 包括具有实验室数据的个人,包括尿液测量棒测试.
- 多变量考克斯回归和Fine&Gray竞争风险模型,以评估与蛋白尿相关的骨折风险,调整共变量.
主要成果:
- 对603,766个人的分析,确定了21,195个骨折.
- 蛋白尿 (痕迹或阳性) 与部或脊椎骨折的风险增加显著相关 (HRs从1.09到1.16不等).
- 结果在子组和敏感性分析中保持一致,在调整功能后证实了相关性.
结论:
- 蛋白尿是部和脊椎骨折的独立危险因素.
- 蛋白尿的存在需要临床关注,以评估骨折风险.
- 常规的蛋白尿尿查可能有助于识别患骨折风险较高的人.
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