患有的妇女的问题和合适的抗发作药物
1Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
患有的女性在月经周期期间经历了发作恶化. 抗发作药物 (ASD) 可以影响口服避孕药,并在怀孕期间构成风险,而拉莫特里金和 levetiracetam 是更安全的选择.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 生殖健康 生殖健康
背景情况:
- 患有的女性 (WWE) 的发作恶化与月经周期阶段 (经期前,排卵) 相相关.
- 抗发作药物 (ASD) 可以影响荷尔蒙避孕药的有效性,并在怀孕和母乳养期间存在风险.
研究的目的:
- 审查及其治疗对妇女生殖健康的影响.
- 讨论WWE中ASD在不同生命阶段的安全性和有效性.
主要方法:
- 关于WWE,月经周期,自闭症的药理动力学和怀孕结果的研究文献综述.
- 对与各种自闭症相关的产性和神经发育风险的分析.
主要成果:
- 诱导酶的ASD加速口服避孕药的新陈代谢;雌激素增加了lamotrigine的新陈代谢.
- 怀孕期间使用氨酸具有最大的重大先天性形和后代智商降低的风险.
- 拉莫特里金, levetiracetam 和oxcarbazepine 在一般人群范围内显示出风险;由于潜在的癌症风险,叶酸补充需要谨慎的剂量.
结论:
- 没有单一的ASD是WWE生育的理想选择,但lamotrigine和 levetiracetam是相对更安全的选择.
- 仔细的ASD选择和管理对于控制发作和在怀孕和母乳养期间最大限度地降低风险至关重要.
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