在B细胞急性淋巴细胞白血病中使用CAR-T细胞疗法
Ugo Testa1, Simona Sica2,3, Elvira Pelosi1
1Istituto Superiore di Sanità, Roma.
Mediterranean journal of hematology and infectious diseases
|January 15, 2024
概括
化学抗原受体T细胞 (CAR-T) 治疗显示了复发性B型急性淋巴细胞白血病 (B-ALL) 的高缓解率. 然而,复发发生,促使研究巩固策略,如干细胞移植和全源CAR-T细胞.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 耐药性和复发性B型急性淋巴细胞白血病 (B-ALL) 在儿童和成人癌症治疗中构成了重大挑战.
- 化学抗原受体T细胞 (CAR-T) 疗法已成为B-ALL的有希望的方法,向CD19,CD20和CD22等抗原.
研究的目的:
- 审查CAR-T细胞治疗在B-ALL中的疗效.
- 探索克服CAR-T治疗后复发的策略,包括全原干细胞移植和全原CAR-T细胞.
主要方法:
- 关于治疗B-ALL的CAR-T细胞治疗的最近研究的综述.
- 对接受CAR-T治疗的患者结果的分析,包括复发率.
- 评估整合性策略,如全原血造干细胞移植 (Allo-HSCT) 和全原CAR-T细胞.
主要成果:
- 在R/R B-ALL.中,CD19 CAR-T细胞实现了高的完全缓解率 (80-90%).
- 大约50%的患者在CAR-T治疗后1-2年内复发.
- 在CAR-T疗法后,Allo-HSCT作为巩固的作用是可变的,并且正在研究其他方法,如来自捐赠者或异质CAR-T细胞.
结论:
- 对于R/R B-ALL,CAR-T细胞疗法是有效的,但长期缓解仍然是一个挑战.
- 为了改善结果,正在探索巩固策略,包括来自供体的CAR-T细胞和全源CAR-T细胞.
- 需要进一步的研究来优化CAR-T细胞治疗和巩固B-ALL患者.
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