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人类乳头瘤病毒感染的宫癌患者的阴道菌群和宫免疫功能之间的相关性

Qiang Wang¹, Wenmin Qin², Wei Gao¹

¹Department of Gynecology and Obstetrics, Suqian Maternity Hospital, Suqian 223800, Jiangsu Province, China.

African health sciences

|January 15, 2024

概括

宫癌患者的高风险HPV感染与阴道菌群变化和CD4+T细胞减少有关. 冠状病毒和Ureaplasma urealyticum是HPV感染的关键危险因素.

科学领域:

妇科妇科医生妇科
免疫学免疫学免疫学
微生物学微生物学

背景情况:

宫癌是全球重要的健康问题.
人类乳头瘤病毒 (HPV) 是导致子宫癌的主要原因.
了解阴道微生物群和宫免疫功能在HPV感染中的相互作用至关重要.

研究的目的:

为了研究阴道菌群组成和宫免疫状况之间的相关性,在HPV感染的宫癌患者.
确定与高风险HPV感染相关的特定微生物和免疫因素.

主要方法:

一组600名患有生殖系统感染的女性被分为高风险HPV组 (n=246) 和对照组 (n=354).
分析了阴道菌群和T淋巴细胞子集 (CD3 +,CD4 +,CD8 +).
使用多变量逻辑回归来确定HPV感染的风险因素.

主要成果:

与对照组相比,高风险HPV组的CD4+T细胞数量和CD4+/CD8+比率显著降低.
在高风险的HPV群体中观察到乳杆菌,克拉米迪亚菌根,Mycoplasma hominis,真菌,Ureaplasma urealyticum和细菌性阴道炎的阳性率较高.
冠状病毒和Ureaplasma urealyticum被确定为高风险HPV感染的独立风险因素.

结论:

宫癌患者的高风险HPV感染与阴道微生物群的失生症和免疫功能受损有关.
甲状腺炎和Ureaplasma urealyticum是重要的独立风险因素,有助于高风险的HPV感染,突出了预防和干预的潜在目标.

关键词:

宫癌是发生在宫癌的原因之一.人类乳头瘤病毒人类乳头瘤病毒免疫功能免疫功能免疫功能阴道菌群阴道菌群

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