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基于它对人类肠道微生物群的影响,重新评估了对泰洛的微生物学上可接受的每日摄入量

Min Ji Kim¹, Ji Young Kim¹, Jang Duck Choi¹

¹Pesticide and Veterinary Drug Residues Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osongsaengmyeong 2-ro, Osong, Cheongju, Chungcheongbuk-do 28159 Republic of Korea.

Toxicological research

|January 15, 2024

概括

本研究确定了鱼类中 tylosin 的基于健康的指导值,发现当使用最新的风险评估方法时,通过饮食暴露于残留物不太可能构成公共卫生风险.

科学领域:

兽医药理学和毒理学兽医药理学和毒理学
水生动物卫生水生动物卫生
食品安全风险评估食品安全风险评估

背景情况:

鱼类有限的兽医药需要重新使用牲畜药物.
泰洛辛是一种有效的牲畜抗生素,被考虑用于水生环境.
需要对鱼类中的泰洛进行最新的毒理和微生物学评估.

研究的目的:

确定鱼类中泰洛的基于健康的指导值 (HBGV) 和最大残留量限制 (MRL).
根据当前的数据和指导方针,重新评估微生物学上可接受的每日摄入量 (mADI).
评估慢性饮食暴露以确认MRL的适当性.

主要方法:

从FSCJ报告中确定了微生物学起点 (0.308μg/mL MIC50).
根据VICH指南,使用修订的结肠内容体积 (500毫升) 更新了mADI导出.
应用了校正因子 (0.224) 来考虑泰洛辛代谢和便结合.
通过比较估计的通过饮食暴露于mADI.计算的危险指数.

主要成果:

微生物学出发点为0.308微克/毫升 (MIC50).
微生物学上可接受的每日摄入量 (mADI) 评估为0.01 mg/kg bw/day.
危害指数不超过100%,表明因慢性暴露于泰洛残留物而引起的公共健康问题较低.
该研究为食品中的兽药残留物风险管理提供了科学依据.

结论:

根据经过修订的微生物风险评估,更新了鱼类中的 tylosin 的 HBGV 和 MRL.
在韩国首次应用mADI概念,用于水生兽药药物残留物的评估.
在拟议的MRL水平下,证实了鱼类中的泰洛残留物的安全性,支持其兽医用途.

关键词:

鱼类鱼类鱼类鱼类微生物学上可以接受的每日摄入量.风险评估风险评估风险评估泰洛西尼 (Tylosin) 是一种药物.

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