紫龙黄泉玉囊通过改善内皮细胞功能障碍来缓解心肌纤维化
Tao Bi1,2, Yanan Zhou1,2, Linshen Mao3
1National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, China.
Journal of traditional and complementary medicine
|January 15, 2024
概括
紫龙黄泉玉囊通过改善内皮细胞功能障碍来缓解心肌纤维化. 这种传统的中医药调节了内皮细胞到介质细胞的过渡和MHC-II的表达,减少了炎症.
科学领域:
- 心血管研究研究心血管研究
- 传统中国医药 传统中国医药
- 细胞生物学 细胞生物学
背景情况:
- 内皮细胞 (EC) 功能障碍是心肌纤维化 (MF) 的关键因素.
- 龙黄通用 (ZL) 囊对多发性肌痛中EC功能障碍的治疗影响尚不清楚.
- 这项研究调查了ZL囊在MF发育期间对EC功能障碍的影响.
研究的目的:
- 为了在体内评估ZL囊在治疗心肌纤维化 (MF) 的疗效.
- 为了确定ZL囊对内皮细胞 (EC) 功能障碍的影响,在MF的背景下.
- 阐明ZL囊发挥治疗作用的基本机制.
主要方法:
- 心肌纤维化 (MF) 模型在体内建立,使用异二醇注射.
- 通过生物标志物分析,心声学和组织学染色 (H&E,Masson,Sirius红色) 来评估ZL囊的治疗效果.
- 免疫光染色以评估ZL囊对EC功能障碍的影响,包括内皮转移到介质酶 (EndMT) 和MHCII类 (MHC-II) 表达.
主要成果:
- 在MF模型中,ZL囊治疗缓解了纤维化和原沉积.
- 分析显示,ZL囊在EC中改善了内皮细胞到介质细胞的过渡 (EndMT) 和MHCII类 (MHC-II) 表达.
- ZL囊通过调节ECs介导的CD4+T细胞激活来减弱炎症反应.
结论:
- ZL囊通过改善内皮细胞 (EC) 功能障碍,证明了对心肌纤维化 (MF) 的治疗作用.
- 该机制涉及调节内皮细胞到介质细胞的转变 (EndMT) 和MHCII类 (MHC-II) 表达.
- ZL囊通过向EC功能障碍和相关炎症,为MF提供了潜在的治疗策略.
相关概念视频
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
432
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
432
Heart Failure Drugs: Inotropic Agents
591
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
591
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Heart Failure Drugs: β-Blockers
341
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
341


