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肠-关节轴:口服益生菌可以改善骨关节炎
Uzma Amin1,2, Rong Jiang3, Shahid Masood Raza4,2
1Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.
Journal of traditional and complementary medicine
|January 15, 2024
概括
益生菌和胺黄油酸 (GABA) 在治疗骨关节炎 (OA) 中表现有前途. 这项肠关节轴研究证明了它们保护关节和减少炎症的能力,为OA提供了潜在的新疗法.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 整形外科 整形外科 整形外科
背景情况:
- 骨关节炎 (OA) 是一个日益严重的全球健康问题,其原因复杂.
- 肠道微生物群显著影响免疫功能和整体健康.
- 目前的研究缺乏对肌肉骨疾病中宿主微生物群相互作用的理解.
研究的目的:
- 研究益生菌 (S. thermophilus,L. pentosus) 和胺黄油酸 (GABA) 在治疗关节炎中的潜力.
- 探索肠-关节轴及其在OA病原和治疗中的作用.
- 评估益生菌/GABA疗法对冠状细胞和关节退化的影响.
主要方法:
- 在体内研究,使用小鼠骨关节炎模型.
- 在体外分析受IL-1β刺激的人类红细胞.
- 在血清和肠道中测量GABA度.
- 评估软骨代谢,关节和软骨细胞中的合成和炎症标志物.
主要成果:
- 益生菌和GABA治疗增加了小鼠的GABA水平.
- 该疗法抑制了软骨的分解,并保护关节免受退化.
- 合成代谢标志物上调,而炎症标志物在小鼠关节和肌肉细胞中减少.
- 在实验室中,GABA在人体红细胞上表现出冠状腺和冠状腺保护作用.
结论:
- 益生菌/GABA疗法在小鼠模型中对骨关节炎关节产生保护作用.
- 这项研究是第一个证明GABA的冠状体和冠状体保护性能的研究.
- 研究结果支持针对肠关节轴治疗骨关节炎的可能性,可能作为辅助疗法.
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