阻塞性睡眠呼吸暂停:成年人患不控制和更严重喘的风险,我们应该密切关注
G Martins Dos Santos1,2, P Simão Coelho1,2, J Gaspar Marques1,2,3
1Department of Allergy and Clinical Immunology, Centro Hospitalar Universitário de Lisboa Central EPE, Lisbon, Portugal.
European annals of allergy and clinical immunology
|January 15, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 在喘患者中很常见,并且与喘控制和严重程度的恶化有关. 对OSA进行查至关重要,特别是在严重或不受控制的喘病例中.
科学领域:
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
- 过敏 过敏是一种过敏.
背景情况:
- 控制喘是多因素的,阻塞性睡眠呼吸暂停 (OSA) 是一个显著的,但变化报告,影响因素.
- 现有的文献显示,有关OSA在喘结果的流行率和影响的结果不一致.
- 了解OSA和喘严重程度/控制之间的联系对于全面的患者管理至关重要.
研究的目的:
- 为了确定成年喘患者中OSA高风险的频率.
- 分析高OSA风险对喘严重程度和控制的影响.
- 在潜在的OSA患者中识别与不受控制的喘相关的因素.
主要方法:
- 在过敏科进行了一项横截面研究,涉及216名成年喘患者.
- 收集的数据包括人口统计,过敏原敏感性,吸烟状态,OSA风险 (柏林问卷),鼻炎控制 (CARAT),喘严重程度 (GINA 2023),喘控制 (ACT),治疗坚持以及肺功能测试.
- 采用多变量分析来识别失控喘的预测因素.
主要成果:
- 在21%的喘患者队列中,发现有OSA的高风险.
- 患有高OSA风险的患者表现出明显更高的失控喘率 (47.8%vs15.8%) 和更严重的疾病 (44.7%vs23.7%).
- 多变量分析显示高OSA风险 (OR 2.81),女性性别 (OR 5.21),不受控制的鼻炎 (OR 3.65),以及GINA步骤4-5治疗 (OR 2.46) 作为不受控制的喘的独立预测因素.
结论:
- 很大一部分喘患者有高风险患上OSA.
- 高OSA风险与较差的喘控制和疾病严重程度的增加密切相关.
- 建议在喘患者,特别是那些患有失控或严重疾病的患者中对OSA进行积极查,以优化管理策略.
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