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血清微RNA-146b表达用于预测未确定的甲状腺结节的甲状腺患者的恶性病变
Amal O Abdelfadeil1, Mohamed R Halawa1, Iman Zaky1
1Department of Internal Medicine and Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
The Egyptian journal of immunology
|January 15, 2024
概括
血清microRNA-146b水平不能预测甲状腺癌的患者在未确定的细针吸收细胞学结果. 然而,较大的甲状腺结节与恶性瘤的风险增加有关.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 分子诊断学 分子诊断
背景情况:
- 甲状腺结节很常见,但区分恶性和良性是具有挑战性的.
- 甲状腺结节的未确定细针吸收细胞学 (FNAC) 结果往往导致不必要的手术.
- 循环中的microRNAs (miRNAs) 显示出作为各种癌症,包括甲状腺癌的生物标志物的潜力.
研究的目的:
- 评估甲状腺癌的血清miRNA-146b表达的预测价值,在没有确定FNAC结果的甲状腺癌患者中.
- 评估血清miRNA-146b水平与甲状腺癌诊断之间的相关性.
主要方法:
- 针对45名甲状腺患者的横截面研究,这些患者甲状腺结核不明.
- 甲状腺超声波和FNAC对所有患者进行.
- 使用实时PCR测量血清miRNA-146b表达,与手术后遗传学相关联.
主要成果:
- 在良性和恶性甲状腺结核之间,血清miRNA-146b表达没有显著差异 (p=0.789).
- 增加的甲状腺结节大小与更高的恶性瘤风险显著相关 (p=0.027).
结论:
- 血清miRNA-146b不是在未确定FNAC的患者中甲状腺恶性瘤的可靠预测指标.
- 甲状腺结节的大小是表明癌症风险增加的重要因素.
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