动脉化的进展:什么,在哪里,在谁身上?
Janine E van der Toorn1,2, Meike W Vernooij1,2, M Arfan Ikram1
1Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
European radiology
|January 15, 2024
概括
动脉化在14年内显著增加,高血压等危险因素会根据性别和动脉对进展产生不同的影响. 仅仅评估一个动脉并不能反映整体动脉样硬化发展.
科学领域:
- 心血管成像和流行病学
- 血管生物学和疾病进展.
- 纵向队列研究是指纵向队列研究.
背景情况:
- 动脉样硬化随着时间的推移而发展并未得到充分记录.
- 了解动脉化中的性别特异性变化至关重要.
- 心血管风险因素对化进展的影响需要进一步研究.
研究的目的:
- 为了评估五大动脉中化体积的长期,性别特定的变化.
- 确定常见心血管风险因素对这些变化的影响.
- 评估动脉样硬化进展的系统性质.
主要方法:
- 一个807名参与者的基于人口的队列在2003年至2006年期间和14年后续进行了CT扫描.
- 评估了冠状动脉结石化 (CAC),大动脉结石化 (AAC),动脉结石化 (CAC) 和脊柱动脉结石化 (VBAC) 的发生率和体积变化.
- 多变量线性回归模型分析了心血管风险因素和化体积变化之间的关联.
主要成果:
- 在男性和女性中都观察到大动脉形化 (AAC) 体积的大幅增加.
- 虽然脊基动脉化 (VBAC) 没有显示体积变化,但在随访期间,超过四分之一的人患有VBAC.
- 高血压始终与化增加有关;其他危险因素显示性别和动脉有不同的关联.
结论:
- 动脉化在14年内显示出相当大的发病率和体积增加.
- 心血管风险因素与化进展有关,具有性别特异性的影响.
- 评估单个动脉中的化可能不代表动脉样硬化的整体系统性发展.
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