实验和密度函数理论研究一些金属氧化物和衍生的纳米集群:对人类费里的比较影响
Zahraa S Al-Garawi1, Ahmad H Ismail2, Duaa H Hillo2
1Department of Chemistry, College of Sciences, Mustansiriyah University, Baghdad, 10001, Iraq. z.mohsin@uomustansiriah.edu.iq.
Discover nano
|January 15, 2024
概括
使用生提取物的氧化 (ZnO) 和氧化铁 (α-Fe2O3) 纳米颗粒的绿色合成显示了治疗糖尿病患者贫血的潜力. ZnO纳米颗粒显示出更高的反应性和更强的与费里的相互作用,这表明了治疗可能性.
科学领域:
- 材料科学和纳米技术
- 生物化学和分子生物学
- 计算化学的计算化学
背景情况:
- 传统的纳米结构合成带来了环境问题.
- 绿色合成为金属氧化物纳米粒子生产提供了一个可持续的替代方案.
- 贫血糖尿病患者需要新的治疗策略,特别是关于费里水平.
研究的目的:
- 用生提取物研究α-Fe2O3和ZnO纳米颗粒的绿色合成.
- 为了评估这些纳米颗粒对贫血糖尿病患者血清费里水平的体外影响.
- 通过计算分析合成纳米粒子的特性和费里结合相互作用.
主要方法:
- 绿色合成α-Fe2O3和ZnO纳米颗粒使用生植物提取物.
- 在使用VIDAS Ferritin测定对贫血糖尿病患者血清费里水平纳米颗粒影响的体外评估.
- 光发光 (PL) 谱学用于结构阐明.
- 密度函数理论 (DFT) 和时间依赖的DFT (TD-DFT) 用于计算分析.
- 分子对接模拟以确定纳米粒子-费里相互作用.
主要成果:
- 通过PL光谱学证实了晶体ZnO和α结构α-Fe2O3纳米粒子的成功绿色合成.
- 计算分析显示,与α-Fe2O3相比,ZnO具有更高的化学反应性和生物活性,由更高的二极极 Moment 值表明.
- 分子对接证明了纳米粒子和人类H链费里之间的强键和金属受体键相互作用.
结论:
- 生提取物辅助绿色合成为生产 ZnO 和 α-Fe2O3 纳米粒子提供了可行的途径.
- 观察到的金属氧化物纳米粒子和费里之间的相互作用表明,在贫血糖尿病患者中管理费里水平的潜在治疗应用.
- 需要进一步的毒理学研究来验证这些纳米颗粒的安全性和疗效.
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