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Updated: Jul 5, 2025

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells
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杀死一个microRNA:目标导向microRNA降解的新兴概念

Amber F Buhagiar1, Benjamin Kleaveland1

  • 1Department of Pathology and Lab Medicine, Weill Cornell Medicine, New York, NY10065, USA.

Nucleic acids research
|January 15, 2024
PubMed
概括

触发性RNAs通过目标导向的miRNA降解 (TDMD) 降解微RNA (miRNA). 这一过程涉及ZSWIM8 E3 泛素酶,对于调节动物的基因表达至关重要.

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