重组疫苗 [RZV] 在炎症性肠病患者中有效:美国倾向匹配队列研究
Aakash Desai1, Jana G Hashash1, Gursimran S Kochhar2
1Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.
Journal of Crohn's & colitis
|January 15, 2024
概括
重组疹疫苗 (RZV) 在50岁及以上的炎症性肠病 (IBD) 患者中显著降低了疹 (HZ) 的长期风险. 这项研究强调了RZV在高风险群体中的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 复合性疹疫苗 (RZV) 在炎症性肠病 (IBD) 患者中提供对疹 (HZ) 的短期保护.
- 对于RZV在IBD患者的长期疗效数据有限.
研究的目的:
- 评估在接受重组疹疫苗 (RZV) 的炎症性肠病 (IBD) 的老年人中发生疹疹 (HZ) 的长期风险.
- 将接受RZV和未接受RZV的IBD患者之间的HZ风险进行比较.
主要方法:
- 使用TrinetX数据库进行回顾性队列研究.
- 包括50岁以上的IBD成年人,将RZV接受者 (IBD-RZV队列) 与非接受者 (IBD控制队列) 进行比较.
- 倾向性得分匹配用于控制混因子;主要结果是事件HZ风险.
主要成果:
- 与IBD控制队列相比,IBD-RZV队列 (n=5489) 的HZ风险明显较低 (aOR 0.44;95% CI 0.32-0.62).
- 在所有年龄组 (50-65岁和>65岁) 和IBD亚型 (性结肠炎和克罗恩病) 中观察到降低的HZ风险.
- 平均随访时间约为900.9天.
结论:
- 在50岁及以上的IBD患者中,RZV与长期降低的HZ风险有关.
- 需要改进疫苗接种策略,以增加这种脆弱人群的RZV吸收率.
- 在IBD患者中,RZV是预防HZ的安全有效选择.
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