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不确定性量化理想化剖析大动脉壁厚度和刚度的不确定性量化

Lise Gheysen¹, Lauranne Maes², Annette Caenen³

¹Institute for Biomedical Engineering and Technology, Electronics and Information Systems, Ghent University, Belgium.

Journal of the mechanical behavior of biomedical materials

|January 15, 2024

概括

计算模型可以改善B型大动脉剖析治疗. 墙壁厚度和度的不确定性显著影响预测的变形和应力,突出了临床决策中需要概率预测的需要.

科学领域:

生物医学工程生物医学工程
计算力学计算力学计算力学
心血管研究研究心血管研究

背景情况:

对B型大动脉剖析 (TBAD) 的个性化治疗可以通过计算模型进行改进.
目前的模型过度简化了TBAD的复杂性,例如虚假光线,眼和物质行为.
非侵入性方法限制了准确的患者特异性墙壁厚度和度捕获,需要模型假设.

研究的目的:

评估墙壁厚度和度的不确定性对TBAD预测墙壁变形和应力的影响.
开发一个以生理学为灵感的有限元素框架,用于建模TBAD墙壁力学.
通过概率预测,为优化治疗决策提供见解.

主要方法:

一个灵感来自生理学的有限元素框架被开发出来,以建模TBAD壁的变形和应力.
300个有限元分析使用拉丁式超立方体采样进行,以评估不确定性.
用高斯过程回归和 δ 时刻独立分析来估计参数特定的不确定性.

主要成果:

全球不确定性分析显示,腹压和心压之间的微小差异.
第4个四分位数包含所有输出参数的大部分不确定性.
材料的刚度和切割膜的相对厚度是墙壁变形和应力的主要决定因素.

结论:

墙壁厚度和度的不确定性显著影响TBAD机械预测.
材料特性和切割膜厚度是影响结果的关键因素.
在TBAD管理中,概率预测对于明智的临床决策至关重要.

关键词:

动脉剖析是一个大动脉剖析.有限元素分析的研究.高斯过程回归的高斯过程回归.不确定性量化不确定性的量化.血管力学血管力学

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