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Updated: Jul 5, 2025

Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype
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双重的HDAC/NAMPT抑制剂在p53-零白血病细胞中克服了最初的耐药性

Kairui Yue1, Simin Sun1, Enqiang Liu1

  • 1Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China.

European journal of medicinal chemistry
|January 15, 2024
PubMed
概括

新型的双重抑制剂,向激素脱乙酶 (HDACs) 和尼古丁胺胺酸转移酶 (NAMPT),显示出强大的抗白血病活性. 这些化合物通过诱导亡来克服p53-null急性髓性白血病的抗性.

关键词:
这是一种抗癌药物.这是一种HDAC抑制剂.希斯脱乙酶的使用多位抑制剂多位抑制剂尼古丁胺胺酸氧化转移酶是什么

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