相关实验视频

Updated: Jul 5, 2025

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

环素A2表达作为肌肉侵入性上道尿路癌的预测生物标志物

Margarete Teresa Walach¹, Katja Nitschke¹, Matthias Groß-Weege¹

¹Department of Urology and Urologic Surgery, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.

Urologia internationalis

|January 15, 2024

概括

高环素A2 (CCNA2) 基因表达预测上道泌尿道癌 (UTUC) 的整体存活时间更长. CCNA2可以作为生物标志物,用于识别肌肉侵入性UTUC不良结果的患者.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

上道泌尿道癌 (UTUC) 是一种罕见的恶性瘤.
对UTUC的预后因素对于患者管理至关重要.

研究的目的:

评估UTUC中Cyclin A2 (CCNA2) 基因表达的预后价值.
评估CCNA2作为总生存率 (OS) 和无疾病生存率的预测指标.

主要方法:

在62名UTUC患者中分析CCNA2,MKI67和p53的基因表达,使用定量逆转录酶聚合酶链反应.
使用卡普兰-梅尔法和考克斯回归进行的生存分析.
在CCNA2,MKI67和p53表达式之间的相关性分析.

主要成果:

高CCNA2表达与较长的寿命相关 (HR 0.33; p = 0.0073).
在多变量分析中,CCNA2过度表达是较长寿命的独立预测因素 (HR 0.37; p = 0.0189).
CCNA2表达与MKI67表达呈正相关性 (Rho = 0.4376; p = 0.0005).

结论:

较低的CCNA2表达与UTUC中较差的OS显著相关.
在肌肉侵入性UTUC中,CCNA2可能作为风险分层的潜在生物标志物.
CCNA2可以帮助识别不良结果的患者,以便在未来进行风险评估.

关键词:

生物标志物生物标志物环A2 环A2 环A2 环总体生存率总体生存率上部通道泌尿器癌癌.

更多相关视频

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

相关概念视频

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

M-Cdk Drives Transition Into Mitosis

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...

Positive Regulator Molecules

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.