全球严重真菌病的发病率和死亡率
1Manchester Fungal Infection Group, University of Manchester, Core Technology Facility, Manchester, UK; Global Action For Fungal Infections, Geneva, Switzerland.
The Lancet. Infectious diseases
|January 15, 2024
概括
每年有数百万人遭受严重的真菌感染,数百万人死亡. 这些估计强调了迫切需要更好的诊断和治疗危及生命的真菌病.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 目前,真菌病负担的估计是不准确的.
- 准确的发病率和死亡率数据对于公共卫生干预至关重要.
- 以前的估计没有完全捕捉到各种真菌感染的全球影响.
研究的目的:
- 为提供重大危及生命的真菌感染的发病率和死亡率的最新和更精确的全球估计.
- 量化可归因的真菌病负担,不包括流感和COVID-19.
- 为公共卫生战略和资源分配提供信息,以控制真菌病.
主要方法:
- 文献搜索 (2010-2023) 和对超过85篇疾病负担论文的分析.
- 使用风险人口分母 (2019-21) 估计发病率.
- 根据治疗率和生存数据计算原始和可归因死亡率.
主要成果:
- 据估计,每年有650万种侵入性真菌感染,导致380万人死亡.
- 侵入性阿斯伯吉洛症影响超过210万人,死亡人数为180万人;慢性肺部阿斯伯吉洛症影响180万人,死亡人数为34万.
- 坎迪达菌血流感染每年导致995,000人死亡;肺囊炎肺炎和Cryptococcal脑膜炎也对死亡率做出了重大贡献.
结论:
- 真菌感染是全球主要的健康威胁,每年造成数百万人的死亡.
- 其中很大一部分 (68%) 的死亡直接归因于真菌感染.
- 改进的诊断,治疗的可访问性和公共卫生意识对于减少真菌病的影响至关重要.
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