糖醇:用于皮肤配方的无处不在的溶剂
1Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia.
概括
糖醇,像乙烯糖醇一样,是有效的药物辅助剂,可以增强通过皮肤透药物. 本次审查澄清了它们改善皮肤药物递送的机制.
科学领域:
- 制药科学 制药科学
- 皮肤药物输送 皮肤药物输送
- 化品制剂的配方 化品的配方
背景情况:
- 糖醇是制药和化品中广泛使用的安全有效的辅助剂.
- 它们的有效性源于它们的优良溶解性和与皮肤脂质和角质素的相互作用.
- 烯基醇是这些应用中特别受欢迎的选择.
研究的目的:
- 巩固现有的关于草甘醇在皮肤药物递送中的作用的文献.
- 阐明糖醇增强皮肤透的机制.
- 为了全面了解糖醇介导的皮肤吸收.
主要方法:
- 文献综述和现有研究的综合.
- 对糖醇与皮肤成分相互作用的分析.
- 检查透增强机制.
主要成果:
- 糖醇显著增强活性化合物的皮肤吸收.
- 与皮肤脂质和角质蛋白的特定相互作用是它们功能的关键.
- 烯基醇在此方面表现出了显著的有效性.
结论:
- 糖醇对于优化皮肤药物输送至关重要.
- 了解它们的透增强机制对于配方开发至关重要.
- 本综述提供了一个统一的观点,在局部应用中的糖醇功能.
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