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在Roux-En-Y胃绕道和袖子胃切除术后,基于疾病严重性得分的2型糖尿病缓解预测模型

Wissam Ghusn¹, Karl Hage², Robert A Vierkant³

¹Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Diabetes research and clinical practice

|January 15, 2024

概括

预测得分有效地识别了代谢和腹部手术 (MBS) 后的2型糖尿病缓解. 个性化代谢手术 (IMS) 和DiaRem得分显示出强大的T2DM缓解后MBS的预测能力.

科学领域:

内分泌学在内分泌学.
腹部外科腹部外科
代谢障碍代谢障碍代谢障碍

背景情况:

代谢和减肥手术 (MBS) 是对肥胖和2型糖尿病 (T2DM) 的高效治疗方法.
一些预测得分 (IMS,DiaRem,先进的DiaRem,罗伯特等等) 在MBS后估计T2DM缓解.
在不同患者队列中验证这些得分,并进行长期随访至关重要.

研究的目的:

验证MBS后T2DM缓解的四个既定预测得分.
根据手术程序 (RYGB与SG) 和手术前的BMI来评估这些得分的有效性.
为了评估IMS的性能,DiaRem,先进的DiaRem,以及罗伯特等人. 在现实世界患者队列中得分.

主要方法:

多中心队列研究涉及503名T2DM患者,他们接受了Roux-en-Y胃旁路术 (RYGB) 或袖子胃切除术 (SG).
计算接收器操作特征曲线 (AUC) 下的面积,以评估每个分数的歧视力.
分析T2DM缓解率,按手术类型和评分严重程度分层.

主要成果:

所有四个评分都显示出对T2DM缓解的良好预测能力 (AUC从0.75到0.79不等).
在Roux-en-Y胃绕道 (RYGB) 显示,与袖子胃切除术 (SG) 相比,T2DM缓解率在各小组中更高.
随着IMS,DiaRem和高级DiaRem得分的严重程度增加,以及较低的Robert et al. 的得分,T2DM缓解率下降. 一个分数,一个分数.

结论:

在IMS,DiaRem,先进的DiaRem,和罗伯特等人. 这些评分是MBS后T2DM缓解的验证预测指标.
手术类型 (RYGB与SG) 影响T2DM缓解率.
这些得分可以帮助患者选择和管理在减肥手术后T2DM缓解.

关键词:

糖尿病缓解缓解的时间糖尿病严重程度得分糖尿病严重程度得分在MBS中,MBS是MBS.这就是T2DM.

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