免疫调节治疗与全身类固醇在炎症性冠状腺新血管化二次到异常多焦点冠状腺炎的治疗
Matteo Airaldi1, Davide Monteduro2, Giovanni Tondini2
1From the Eye Clinic (M.A., D.M., G.T., F.Z., M.O., G.S., A.I.), Department of Biomedical and Clinical Science, Luigi Sacco Hospital, University of Milan, Milan, Italy; Department of Molecular and Translational Medicine (M.A.), University of Brescia, Brescia, Italy.
American journal of ophthalmology
|January 15, 2024
概括
免疫调节疗法 (IMT) 与类固醇相比,在多焦性胆道炎 (MFC) 患者中改善了视觉结果,并减少了炎症性胆道新血管化 (iCNV) 的并发症. 加强炎症控制是预防视力丧失的关键.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性胆道新血管化 (iCNV) 是多焦胆道炎 (MFC) 的一种视力威胁的并发症.
- 标准治疗通常涉及类固醇,但结果可能是可变的.
研究的目的:
- 为了比较免疫调节疗法 (IMT) 与类固醇治疗iCNV在MFC患者的疗效.
- 在2年的随访期间评估视力敏度和治疗结果.
主要方法:
- 一个多中心的回顾性匹配队列研究比较IMT和"必要时使用类固醇"组.
- 关键结果包括视力敏度 (VA),抗VEGF注射和iCNV重新激活率.
- 根据诊断到治疗的时间,患者被匹配.
主要成果:
- IMT组显示iCNV再激活 (RR 0.64) 和反VEGF再处理 (RR 0.59) 的风险明显较低.
- 复发的MFC与iCNV重新激活的风险增加有关 (RR 1.22).
- 在IMT组中观察到更高的最终VA (77.1 vs 69.1字母) 和更大的VA收益 (+2.5字母/年).
结论:
- 与类固醇相比,IMT与MFC中iCNV的优异视觉和治疗结果有关.
- 有效控制潜在的MFC炎症对于预防iCNV复发和维护视力至关重要.
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