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在患有低酸血症的患者中FGF23升高的患病率

Charlotte Oris¹, Alexandre Lautrette², Aurore Dougé³

¹Biochemistry and Molecular Genetics Department, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France; Clermont Auvergne University, CNRS, INSERM, iGReD, Clermont-Ferrand, France.

Clinica chimica acta; international journal of clinical chemistry

|January 15, 2024

概括

纤维细胞生长因子23 (FGF23) 的升高是低酸血症的重要原因,影响超过10%的患者. 早期FGF23测量对于准确的诊断和改善患者管理至关重要.

科学领域:

内分泌学在内分泌学.
腎臟病學 (nephrology) 是一種醫學專業.
在瘤学瘤学.

背景情况:

低酸性血是一种常见的电解质疾病,具有不同的病因.
纤维细胞生长因子23 (FGF23) 在不明原因的低酸血症中的作用需要进一步研究.
了解FGF23的贡献对于准确的临床诊断至关重要.

研究的目的:

为了确定高FGF23在低酸血症患者的患病率.
确定FGF23相关的低酸性乱的潜在机制.
在临床实践中评估FGF23测量的诊断效用.

主要方法:

一项前性,观察性,多中心队列研究,涉及260名低酸血症患者.
测量血清FGF23,副甲状腺激素 (PTH),1,25-二氧维生素D,骨性酸酶和25-氧维生素D.
对FGF23水平的分析和相关病因的分类.

主要成果:

在10.4%的低酸血症病例中发现FGF23升高 (>95.4 pg/mL).
至少十分之一的低酸血症病例可能由于未被识别的FGF23升高而被错误归因.
鉴定FGF23升高的原因包括脏病理,恶性瘤和术后并发症.

结论:

血FGF23测量应纳入常规评估低酸血症.
准确诊断FGF23相关疾病可以改善患者管理.
进一步研究FGF23在代谢性骨疾病中的作用是有必要的.

关键词:

联邦政府财政基金23 低酸盐血症是什么情况流行程度流行程度瘤是一个瘤.

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