免疫检查点针对树突细胞进行基于抗体的癌症调节
Xin Lei1, Yizhi Wang1, Chayenne Broens1
1Department of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
International review of cell and molecular biology
|January 15, 2024
概括
树突细胞 (DCs) 对于抗瘤免疫至关重要,弥合先天性和适应性反应. 了解DC上的免疫检查点蛋白如何影响瘤微环境中的T细胞反应,对于开发新的癌症免疫疗法至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 细胞免疫学 细胞免疫学
背景情况:
- 树突细胞 (DCs) 是关键的抗原呈现细胞,连接先天性和适应性免疫.
- DCs调节瘤排水淋巴结 (TDLN) 和瘤微环境 (TME) 中的抗瘤T细胞反应.
- 瘤微环境 (TME) 抑制因素通常会损害DC功能,导致瘤免疫逃逸.
结论:
- DCs对于启动和维持T细胞对癌症的免疫力至关重要.
- 在TME中DCs的精确状态和功能对于有效的抗瘤反应至关重要.
- 针对DC的ICP有望提高癌症免疫疗法的疗效.
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