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Updated: Jul 5, 2025

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
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最近瘤微环境规划的进展,用于免疫检查点疗法中的目标选择和响应预测,通过空间蛋白质复杂化分析实现了这一目标

Madhavi Dipak Andhari1, Asier Antoranz1, Frederik De Smet1

  • 1Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium; The Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.

International review of cell and molecular biology
|January 15, 2024
PubMed
概括

高维空间技术正在通过发现新的生物标志物来彻底改变癌症免疫疗法. 这些先进的工具可以改善患者选择免疫检查点疗法,提高治疗效率并减少不良影响.

关键词:
免疫检查点疗法 免疫检查点疗法空间蛋白质复杂化的空间蛋白质复杂化瘤微环境的表征

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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