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Updated: Jul 5, 2025

Detection of Axonally Localized mRNAs in Brain Sections Using High-Resolution In Situ Hybridization
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FMRP调节的aggrecanmRNA翻译控制周神经元净发育

Heleen M Van't Spijker1, Joel D Richter1

  • 1Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

Journal of neurochemistry
|January 15, 2024
PubMed
概括

脆弱X综合征通过影响周神经网络 (PNN) 破坏大脑发育. 失去FMRP蛋白质会损害aggrecan mRNA的翻译,影响PNN的形成和神经元激发/抑制平衡.

关键词:
在FMRP中使用FMRP.农业可以可以 aggrecan.脆弱的X综合征 脆弱的X综合征周神经神经网络

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