在挪威母亲,父亲和儿童队列研究中,使用多基因分数检查行为问题的代际风险因素
Leonard Frach1, Wikus Barkhuizen2, Andrea G Allegrini2,3
1Department of Clinical, Educational & Health Psychology, Division of Psychology & Language Sciences, Faculty of Brain Sciences, University College London, London, UK. leonard.frach.20@ucl.ac.uk.
Molecular psychiatry
|January 15, 2024
概括
遗传传染,而不是遗传培养,显著影响孩子的行为问题. 这项研究使用了母亲-父亲-孩子三人组的多基因分数来分析对行为的遗传和环境影响.
科学领域:
- 行为遗传学 行为遗传学
- 发展心理学 发展心理学
- 精神病学流行病学 精神病学流行病学
背景情况:
- 儿童的行为问题有复杂的起源,涉及遗传和环境因素.
- 父母的特征在儿童发育中起着至关重要的作用,需要了解遗传和环境传播途径.
- 区分直接的遗传传染和间接的遗传影响 (遗传培养) 是理解行为问题的病因的关键.
研究的目的:
- 研究遗传传染和遗传培养在行为问题的发展中的作用.
- 分析父母多基因分数 (PGS) 对儿童行为问题的影响.
- 为了区分直接遗传与环境间接遗传影响的贡献.
主要方法:
- 利用来自挪威母亲,父亲和儿童队列研究 (MoBa) 的31,290个母亲-父亲-孩子三人组的数据.
- 使用了13个与精神疾病,物质使用和教育因素相关的多基因分数 (PGS) 来评估遗传影响.
- 分析了8岁和14岁儿童的母亲或自我报告的行为问题.
主要成果:
- 在8岁的13名PGS中的12名和14岁的13名PGS中的4名中观察到对行为问题的显著遗传效应.
- 最强的遗传传染效应与8岁吸烟的PGS相关 (β=0.07).
- 没有发现任何显著的遗传培养效应行为问题使用选定的PGS.
结论:
- 这些发现支持了从父母传给孩子的直接遗传在父母特征和儿童行为问题之间的关联中发挥的作用.
- 根据研究的多基因分数进行索引的遗传培养似乎对行为问题具有有限的病因重要性.
- 进一步的研究可能会探索较小的遗传培养效应或父母特征的影响,这些特征并未被当前的多基因分数所捕获.
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