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Updated: Jul 5, 2025

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使用AlphaFold系统地发现蛋白质相互作用接口,并进行实验验证

Chop Yan Lee1, Dalmira Hubrich1, Julia K Varga2

  • 1Institute of Molecular Biology (IMB) gGmbH, 55128, Mainz, Germany.

Molecular systems biology
|January 15, 2024
PubMed
概括

AlphaFold-Multimer对预测蛋白质结构,特别是使用特定蛋白质碎片化的域-动机相互作用显示出希望. 这种方法在神经发育障碍中确定了与疾病相关的新型接口,提供了新的分子洞察力.

关键词:
阿尔法折叠是什么意思阿尔法折叠基准测试 (benchmarking) 是一种比较的方法.实验验证的验证线性图案 线性图案 线性图案蛋白质相互作用接口预测

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