儿童开始的IgA病:长期康复是可能的吗?
Luca Antonucci1,2, Laura Fuiano1, Antonio Gargiulo1
1Division of Nephrology, Bambino Gesù Children's Hospital - IRCCS, Piazza S. Onofrio 4, 00165, Rome, Italy.
Pediatric nephrology (Berlin, Germany)
|January 15, 2024
概括
大约三分之一的儿科IgA脏病患者 (IgAN) 达到完全的临床缓解. 发病时年龄较小,没有淋巴结核硬化症,提高了康复的机会.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 儿科脏病学 儿科脏病学
- 淋巴细胞疾病 淋巴细胞疾病
背景情况:
- 在全球范围内,IgA腎病 (IgAN) 是最常見的膠質膠質腎炎.
- 重点是疾病的进展,关于恢复可能性的数据有限.
研究的目的:
- 为了确定在儿科IgA脏病中完全临床缓解的可能性.
- 确定与在IgAN中实现缓解相关的因素.
主要方法:
- 对153名儿科Igan患者 (1986-2018) 的回顾性单中心研究.
- 用于活检评分的MEST-C牛津分类.
- 完全缓解被定义为缺乏蛋白尿,血尿,高血压,与正常的功能停止治疗>2年.
主要成果:
- 在153名患者中,有41名患者实现了完全的临床缓解.
- 估计完全缓解的10年概率为43%.
- 较高的发病年龄和细分性淋巴结核硬化病变显著降低了缓解的机会. 免疫抑制疗法没有显著的关联.
结论:
- 大约三分之一的儿科Igan患者实现了长期缓解.
- 没有硬化病变的非常小的孩子有更好的缓解前景.
- 需要进行更长的随访,以确认永久缓解状态.
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