在维生素D试验中,从产前期到6-8岁的低级炎症
Helena H Hauta-Alus1,2,3,4, Jenni Rosendahl5,6, Elisa M Holmlund-Suila5,6
1Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. helena.hauta-alus@helsinki.fi.
Pediatric research
|January 15, 2024
概括
儿童炎症,通过高灵敏度C反应蛋白 (hs-CRP) 测量,从出生到8岁持续存在. 较高的维生素D水平,而不是剂量,与儿童的hs-CRP增加相关,这表明早期炎症会影响长期健康.
科学领域:
- 儿科健康 儿科健康
- 炎症生物标志物 炎症生物标志物
- 营养免疫学 营养免疫学
背景情况:
- 低度系统性炎症,由高灵敏度C反应蛋白 (hs-CRP) 表示,与非传染性疾病风险有关.
- 产前炎症和儿童早期的维生素D状况可能会影响儿童的持续性炎症.
研究的目的:
- 为了研究产前炎症和婴儿早期维生素D水平与炎症标志物之间的关联,直到6-8岁.
- 为了确定从出生到幼儿时期的炎症的持续性.
主要方法:
- 对孕妇,带血 (UCB) 和1,2岁和6-8岁的后代的血液hs-CRP和25-氧维生素D[25(OH) D的分析.
- 利用了来自婴儿维生素D干预 (VIDI) 随机对照试验的数据,包括维生素D补充手臂.
主要成果:
- 较高的UCB hs-CRP独立地与高的hs-CRP水平相关,持续到6-8岁.
- 婴儿维生素D补充剂剂量没有影响纵向hs-CRP水平.
- 增加的儿童25(OH) D度显示出与hs-CRP的积极关联,直到6-8岁.
结论:
- 通过hs-CRP评估的儿童炎症,显示从出生到8岁的持续性.
- 维生素D充足度与儿童hs-CRP水平之间存在积极的关联.
- 由于炎症引起的慢性疾病风险可能起源于产前期或幼儿时期.
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