在瘤微环境中细菌的殖民化为免疫性化疗创造了有利的利基
See-Khai Lim1, Wen-Ching Lin1, Sin-Wei Huang1
1Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
EMBO molecular medicine
|January 15, 2024
概括
引入免疫性化疗的细菌,如氧沙,有效地打击瘤微环境 (TME). 这种组合消除了瘤,并在小鼠中建立了持久的抗瘤免疫力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 瘤微环境 (TME) 施加差异选择性压力 (DSP),有利于癌细胞生长,通常压倒单价疗法.
- 目前的治疗方法在免疫抑制TME中努力扭转癌细胞的主导地位.
研究的目的:
- 探索使用细菌改变DSP用于瘤根除的组合治疗策略.
- 研究细菌与不同化疗剂对抗瘤免疫力的协同作用.
主要方法:
- 将细菌作为外来物种引入TME.
- 服用选择性化疗药物 (oxaliplatin,5-FU) 和禁食与细菌结合使用.
- 评估小鼠的瘤生长,免疫激活 (先天性和适应性) 和免疫记忆.
主要成果:
- 癌症选择性化疗和与细菌相结合的禁食,对瘤生长产生了强大的选择压力.
- 奥克萨利普拉丁是一种免疫药物,与细菌协同激活先天性和适应性免疫力,从而导致完全的瘤缓解和持续的抗瘤免疫记忆.
- 牛氧-细菌组合显著增强了抗原呈现细胞上的共刺激和抗原呈现分子,促进了细胞毒性T细胞介导的癌细胞杀死.
结论:
- 细菌疗法和免疫性化疗的合理组合可以克服免疫抑制性TME.
- 这种组合方法促进了强大的抗癌免疫力,为瘤根除提供了有前途的策略.
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